Week 1 of the 2021 NFL season pits two teams hoping for a better year after a tough 2020. The San Francisco 49ers head to the midwest to battle against the Detroit Lions.This matchup is intriguing for a slew of reasons. The 49ers suffered an injury crisis in 2020 that scuppered their Super Bowl chances. After spending the entire offseason retaining their stars and adding more talent to the roster, the 49ers have their sights on reclaiming the NFC West crown. The Lions, meanwhile, are in year one of a long rebuild; it is evaluation time for many players in the Motor City. They must perform.Match DetailsFixture - San Francisco 49ers vs. Detroit LionsDate & Time - Sunday, September 12th 1: PM ESTVenue - Ford Field, Detroit, MichiganDetroit Lions Week 1 PreviewThe Lions enter Week 1, starting a new era. Former Lion Dan Campbell is back to lead his team in a coaching capacity. The Lions roster has undergone major surgery. The headline change was the team swapping Matthew Stafford for Jared Goff. The former Los Angeles Rams starting quarterback arrives in Detroit hoping to restore his reputation after two underwhelming seasons.The Lions also got younger on defense. Out went the old Patriots stalwarts; the coaching staff has decided to give youth a chance. The Lions have injury concerns surrounding star left tackle Taylor Decker. He will miss the Week 1 game, and the Lions will have to reshuffle their offensive line. Rookie Penei Sewell may start at left tackle in Decker's absence.Campbell said Decker hurt the hand, which is more of a finger, during Wednesday’s practice. Seeing doctor today. Campbell said it doesn’t look good for Decker to play Sunday vs. San Francisco— Tim Twentyman (@ttwentyman) September 10, 2021Key Player - T. J. HockensonT. J. Hockenson is a burgeoning star at the tight end position. The Iowa State alum made the Pro Bowl last year for the first time in his NFL career. He'll be determined to follow up his 2020 campaign with another good season.Hockenson is the best pass-catcher on the Lions roster. The 49ers' defense will test him, but he has spent the offseason working out and training alongside George Kittle and that should help him take his game to the next level. Furthermore, Hockenson's built a strong relationship with Goff. The quarterback will rely on Hockenson in crucial situations to move the sticks.Detroit Lions Week 1 Predicted LineupQuarterback - Jared Goff, David BloughRunning Back - D'Andre Swift, Jamaal Williams, Jemar Jefferson, Godwin IgwebuikeFull Back - Jason CabindaWide Receiver - Tyrell Williams, Amon Ra St. Brown, Kalif Raymond, Tom Kennedy, Trinity BensonTight End - TJ Hockenson, Darren FellsOffensive Linemen - Frank Ragnow, Logan Stenberg, Matt Nelson, Penei Sewell, Halapoulivaati Vaitai, Jonah JacksonDefensive Linemen - Michael Brockers, Alim McNeill, Levi Ownwuzurike, John Penisni, Nick Williams, Kevin StrongLinebacker - Trey Flowers, Romeo Okwara, Charles Harris, Austin Bryant, Julian Okwara, Alex Anzalone, Jamie Collins, Jalen Reeves MaybinCornerback - Jeff Okudah, Amani Oruwayire, Ifeatu Melifonwu, AJ Parker, Bobby PriceSafety - Tracy Walker, WIll Harris, Dean Marlowe, CJ MooreKicker - Austin SeibertPunter - Jack FoxReturner - Kalif RaymondSan Francisco 49ers Week 1 PreviewLas Vegas Raiders v San Francisco 49ersWeek 1 offers the 49ers a shot at redemption. After going so close in 2019, the 49ers' 2020 season was wrecked due to injuries. The 49ers are now healthy and desperate to get back to the big game.With Jimmy Garoppolo healthy, the 49ers can unleash their full offensive playoff. Deebo Samuel, Brandon Aiyuk and George Kittle will feature heavily in the passing and running game.Rookie Trey Lance should feature as well. Shanahan has designed specific plays and packages for the exciting rookie.This throw from Trey Lance 👀👀 @treylance09 @THE2ERA (via @49ers)pic.twitter.com/SjIBzB0hRW— The Checkdown (@thecheckdown) August 7, 2021Key Player - Nick BosaNick Bosa is one of the dominant pass-rushers in the NFL. The younger Bosa brother is back from injury and he'll be salivating at the opportunity in Week 1.Left tackle Taylor Decker will miss the game. Rookie Penei Sewell will slide to Goff's blindside to take on Bosa. Sewell has not played left tackle since 2019 after he opted out of the 2020 college football season due to COVID-19 concerns. It will be a challenging Week 1 assignment for the rookie. Bosa could dominate and pressurize Jared Goff all game long in Week 1.San Francisco 49ers Week 1 Predicted LineupQuarterback - Jimmy Garoppolo, Trey LanceRunning Back - Raheem Mostert, Trey Sermon, JaMycal HastyFull Back - Kyle JuszczykWide Receiver - Deebo Samuel, Mo Sanu, Brandon Aiyuk, Trent SheffieldTight End - George Kittle, Ross DwelleyOffensive Linemen - Alex Mack, Mike McGlinchey, Tom Compton, Daniel Brunskill, Laken TomlinsonDefensive Linemen - Arik Armstead, Dee Ford, Nick Bosa, Javon Kinlaw, Samson Ebukam, DJ JonesLinebacker - Fred Warner, Dre Greenlaw, Azeez Al Shaalr, Marcell HarrisCornerback - Emmanuel Mosely, Ambry Thomas, Josh Norman, Demmodore Lenoir, K'Wuan Williams, Jason VerrettSafety - Jimmie Ward, Talanoa Hufanga, Jaquiski Tartt, Tavon WilsonKicker - Robbie GouldPunter - Mitch WishnowskyReturner - Elijah Mitchell, Brandon AiyukLions vs. 49ers Week 1 Match PredictionA motivated Detroit Lions team will start the game at high speed and high intensity. That will fade as the experienced 49ers settle into the game and take control. The 49ers will win comfortably in the late stages by two scores in this Week 1 game.