Dallas Cowboys vs Philadelphia Eagles predictions, odds, and picks for Week 1 TNF clash

Week 1 of the 2025 NFL season kicks off with a Thursday Night Football clash between the Dallas Cowboys and Philadelphia Eagles. The defending Super Bowl champions will raise their banner, but their NFC East divisional rivals will attempt to spoil the celebration.

Here's a preview of the matchup, along with how things could play out.

Dallas Cowboys vs Philadelphia Eagles: Game Details

Fixture: Dallas Cowboys at Philadelphia Eagles on TNF

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Date & Time: Thursday, Sept. 4, 2025 at 8:20 PM ET

Venue: Lincoln Financial Field in Philadelphia, Pennsylvania

Dallas Cowboys vs Philadelphia Eagles: Betting Odds (via BetMGM)

Spread

Cowboys (+8.5)

Eagles (-8.5)

Moneyline

Cowboys (+350)

Eagles (-450)

Total

Over / Under (47.5)

Dallas Cowboys vs Philadelphia Eagles: Picks

One of the most intriguing prop bets for this Week 1 matchup is to take over 37.5 receiving yards for Jake Ferguson. The tight end averaged 45 yards per game two years ago in his last season with Dak Prescott healthy. This makes the over a valuable pick this week.

Another option is to take over 33.5 rushing yards for Javonte Williams in his Cowboys debut. He is reportedly expected to serve as their starter against the Eagles, and while Jaydon Blue and Miles Sanders could be in the mix for carries, his low total is an attractive bet.

Dallas Cowboys vs Philadelphia Eagles: NFL Injury Report

Cowboys

DT Perion Winfrey (Back) - OUT

Eagles

QB Tanner McKee (Thumb) - OUT

Dallas Cowboys vs Philadelphia Eagles: Head-to-Head

The Cowboys lead the all-time series 74-58 over the Eagles. Dak Prescott has found success against his divisional rivals, owning a 9-4 career record. Jalen Hurts has been less successful, with a 4-3 record ahead of their Week 1 clash.

Dallas Cowboys vs Philadelphia Eagles: Prediction for Week 1

The Eagles will enter this Week 1 matchup as favorites, but an upset is possible. Prescott's career record against Philadelphia suggests he has a shot of opening the 2025 NFL season with an underdog victory.

The Cowboys also made a significant upgrade to their offense during the offseason, adding George Pickens to finally give them the explosive WR2 they have been seeking. The Eagles are essentially returning the same offense from last year, which isn't a bad thing, considering Saquon Barkley was the Offensive Player of the Year.

Prediction: Cowboys 26, Eagles 20

About the author

Adam Hulse is an NFL journalist at Sportskeeda with 4 years of experience. He is also the host of the podcast "Sports Talk with Adam Hulse."

Adam studied Communications at Villanova University and played American football at Pop Warner and as a high school Freshman. His favorite team are the Dallas Cowboys, and if Adam could lay his hands on a time machine, he would love to witness their glory years from the 1990s. The Cowboys' 27-17 win over the Pittsburgh Steelers in Super Bowl XXX is his favorite Super Bowl of all time.

Given his affinity for 'America's Team,' Adam's favorite players of all time include Emmitt Smith. Michael Irvin, Tony Romo and Dak Prescott.

Adam takes a lot of pride in his work, which naturally culminates into insightful content for his readers, performance analysis being his forte. When not writing about football, Adam spends a time on his podcast.

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Edited by Adam Hulse