Southampton continue their Premier League 2021-22 campaign on Saturday as they welcome Chelsea to St. Mary's Stadium.The hosts picked up a point across all competitions for the first time in over a month as they came from behind to secure a 1-1 draw at Leeds United last week. They had lost three games in a row before that encounter.Chelsea, on the other hand, resumed their campaign following the international break with a 4-1 home loss to London rivals Brentford last week. Their poor run continued in the UEFA Champions League as well, as they suffered a 3-1 home loss to Real Madrid in their first-leg quarter-final fixture on Wednesday.The two sides head into the game with just one thing on their minds, which is to secure a win. Chelsea's second-leg game in the Champions League just four days after this fixture might impact their performance here.Squawka@SquawkaMost free-kicks scored in the Premier League since the start of last season: ◉ 7 - James Ward-Prowse ◎ 4 - Newcastle◎ 3 - Arsenal◎ 3 - Leeds Whip it like Ward-Prowse. 8:45 AM · Apr 2, 20221222140Most free-kicks scored in the Premier League since the start of last season: ◉ 7 - James Ward-Prowse ◎ 4 - Newcastle◎ 3 - Arsenal◎ 3 - Leeds Whip it like Ward-Prowse. 🎯 https://t.co/h5ln4pmzxeSouthampton vs Chelsea Head-to-Head and Key NumbersThe two Southern England rivals have locked horns 110 times across all competitions. Chelsea lead 48-31 in wins while 31 games have ended in draws.This will be the third meeting between the two sides this season, with Chelsea emerging victorious in the two games played at Stamford Bridge. Chelsea knocked the Saints out of the Carabao Cup on penalties in October.Only Crystal Palace (13) and Brighton (13) have played more draws than the hosts in the Premier League this season (12).The Blues are the only team without a goal from counter-attacking play in the league alongside Burnley, Leeds United, and Brighton this season.Chelsea have never lost consecutive games in the Premier League under Thomas Tuchel.The two sides have played out a goalless draw just twice in the Premier League era.Southampton vs Chelsea PredictionSouthampton are without a win against the London giants at home since 2013, with their last two wins in the fixture coming at Stamford Bridge. They have lost their last two home games by a 2-1 scoreline and will be looking to return to winning ways here.Chelsea are undefeated in their last four away games, scoring nine goals in that period and conceding just twice. Their odds of defeating the home side look good and they will also be fired up after a 3-1 thrashing at home in the Champions League by Real Madrid.Chelsea FC@ChelseaFCAttention now turns to #SouChe this weekend. 4:18 AM · Apr 7, 2022128921092Attention now turns to #SouChe this weekend. 👊 https://t.co/glyRT0fmEmChelsea should come out on top here but we also expect the Saints to put up a fight and score at least one goal.Prediction: Southampton 1-2 Chelsea$1,100 First Bet Insurance at CaesarsSouthampton vs Chelsea Betting TipsTip 1: Result - Chelsea.Tip 2: Both teams to score - Yes.Tip 3: Goals - Over/under 2.5 - Over 2.5 goals.Tip 4: Chelsea to score first - Yes (The Blues have scored first in their last seven league games)Tip 5: Yellow cards - Over/under 1.5 - Over 1.5 Yellow cards