Defending LaLiga Santander champions Real Madrid tasted defeat for the first time this season as newly-promoted Cadiz registered a shock win against them at the Estadio Alfredo Di Stefano.Honduran star Anthony Lozano gave the visitors a lead in the 16th minute after he was left unmarked and he managed to lob the ball past a helpless Thibaut Courtois. Los Blancos, who started the game without the likes of Casemiro, Fede Valverde, and other key players in the side, saw the lion's share of the ball, finishing the game with a staggering 75% possession.🏁 FP: @realmadrid 0-1 @Cadiz_CF⚽ Lozano 16'#Emirates | #HalaMadrid pic.twitter.com/3RRht3OJqn— Real Madrid C.F. (34🏆) (@realmadrid) October 17, 2020Zinedine Zidane rang in the changes at half time as the likes of Valverde, Casemiro, and Marco Asensio were all introduced ahead of the second 45 minutes as he hoped to get a response from his side. Eder Militao was also thrown into the fray for the second half after Sergio Ramos, already on a yellow, picked up a knock and had to play through the pain barrier.However, it all counted for nothing as Real Madrid could do nothing to break down a stubborn Cadiz side. Real Madrid lost at home to Cadiz 🙃 pic.twitter.com/bxYv35mS8A— Goal (@goal) October 17, 2020Veteran striker Alvaro Negredo was a constant threat to the Real Madrid defence and won a whopping 11 of his 15 (!) aerial duels, and set up Lozano for the only goal of the game, which proved to be the winner. Lozano was also formerly on the books of Barcelona B, making it an even more poetic series of events in the grand scheme of things.This was the first loss that Real Madrid faced in their last 15 games, and the timing of the loss is even more crucial as it comes just a week before the crucial El Clasico showdown at the Nou Camp.Here are some of the best tweets from Real Madrid's shocking home defeat to newly-promoted Cadiz!Cadiz snaps Real Madrid's 15-game unbeaten streak in La Liga 😯 pic.twitter.com/MC2u5gmHjg— ESPN FC (@ESPNFC) October 17, 2020Four of the five teams that won Europe's top five leagues last season have already suffered a league defeat this campaign:❌ Liverpool (2-7 vs. Villa)❌ Bayern (1-4 vs. Hoffenheim)❌ PSG (0-1 vs. Lens, Marseille)❌ Real Madrid (0-1 vs. Cadiz) 🆕Your move, Juve. 😉 pic.twitter.com/WDH6SQOQEG— Squawka Football (@Squawka) October 17, 2020Anthony "Choco" Lozano was at Barcelona a couple of years ago, played for their B team, didn't make a mark. Came to Cadiz on loan from Girona, helped them enter the top division with a terrific performance. Now scores a winner against Real Madrid. Wowsie. #RealMadridCadiz— anuraagpeesara15 (@anuraagp15) October 17, 2020👑 - Real Madrid against promoted opposition in La Liga in home matches❌✅✅✅✅✅✅✅✅↔️✅✅✅✅✅✅✅✅✅✅✅✅✅✅✅✅✅✅✅✅✅✅✅✅✅✅✅✅✅✅✅#RealMadridCadiz #LaLiga— Gracenote Live (@GracenoteLive) October 17, 2020Absolutely fantastic result for newly-promoted Cádiz taking down Real Madrid away from home for the first time in their history 🔥Their 3rd win in 6 games to go tied top of LaLiga on 10 points. Incredible start to the season 💪🏻 https://t.co/QWYPsKWSk1— Andrew Miller (@AndrewMillerNBA) October 17, 20201 - @Cadiz_CFEN won a @LaLigaEN game against Real Madrid for the fourth time (D3 L18), the first since March 1991 (1-0), and for the first time in a LaLiga away game (D1 L11). Historic. pic.twitter.com/pd6xLkuG18— OptaJose (@OptaJose) October 17, 2020Cadiz's match winner vs. Madrid Choco Lozano had spell at Barça a few years ago, playing for B team in 17-18. Barça will go level with Madrid if they win tonight (having played a game less) ahead of Clasico next weekend— Samuel Marsden (@samuelmarsden) October 17, 2020Real Madrid have suffered their first home defeat in LaLiga in 399 days.At the hands of newly-promoted Cadiz, who now go level on points with them at the top of the table. 😳 pic.twitter.com/lkXma2eYVH— Squawka Football (@Squawka) October 17, 2020When you have just taken your newly promoted Cádiz side to Valdebebas, outbattled and outplayed Real Madrid, and won 1-0, then this is the reaction. Her served by manager Álvaro Cervera. pic.twitter.com/qa9kbbflKc— Jonas Giæver (@CheGiaevara) October 17, 2020The thing about Real Madrid is that we’re either winning 3 CL titles in a row, or everyone looks worse than a Kepa vs Maguire disasterclass compilation. It’s always Russian roulette with this football institution.— Xav Salazar (@XavsFutbol) October 17, 2020FT: Real Madrid 0-1 CadizFirst Real Madrid loss at the ADS.First Cadiz win vs Real Madrid since 1991.First Real Madrid loss after 15 consecutive games. pic.twitter.com/BCLzt3XCUX— M•A•J (@Ultra_Suristic) October 17, 2020Cádiz wins 1-0 at Real Madrid on a goal by Honduran Choco Lozano. Real Madrid tests positive for the FIFA flu.— Grant Wahl (@GrantWahl) October 17, 2020📅 2th Mar 1991🔙💛 Cadiz 1-0 Real Madrid📅 17th Oct 2020🆕💛 Real Madrid 0-1 CadizAfter beating Di Stefano's Real Madrid, they had to wait 29 years to beat them again (at the Alfredo di Stefano 😱).👏 𝗖𝗢𝗡𝗚𝗥𝗔𝗧𝗦, @Cadiz_CFEN! 👏#RealMadridCadiz pic.twitter.com/JNWjll79EM— LaLiga English (@LaLigaEN) October 17, 2020🔙 Back in the top-flight for the first time in 14 years🤯 Second in La Liga on goal difference having just beaten champions Real Madrid🤩 The stuff of dreams for Cadiz pic.twitter.com/ZLOUvXKBah— WhoScored.com (@WhoScored) October 17, 2020A historic win that moves @Cadiz_CF to 2nd on the table (temporarily) as JOINT-LEADERS with Real Madrid and fellow Andalusian side Granada on 10pts. Remarkable. 👏#RealMadridCadiz #LaLigaSantander pic.twitter.com/7p1QZ7rkLb— Semra Hunter (@SemraHunter) October 17, 2020Great performance from Cadiz, consistently playing Madrid's forwards offside, and they were solid overall. But, it's the first time in a very long time that I can't pick one positive out of a game for Madrid. From start to finish, appalling and unacceptable.— Muddassir Hussain (@muddassirjourno) October 17, 2020