The Coppa Italia is back in action with a set of Round of 16 fixtures this week as Napoli take on Fiorentina on Wednesday. Both teams have impressive players in their ranks and have a point to prove this week.Fiorentina are in seventh place in the Serie A standings and have been fairly inconsistent this season. La Viola suffered a shock 4-0 defeat against Torino over the weekend and cannot afford a similar debacle in this fixture.Napoli, on the other hand, are in third place in the league table at the moment and have excelled this season. The Neapolitans edged Sampdoria to a 1-0 victory in their previous game and will be confident ahead of this match.Official SSC Napoli@sscnapoliAP #ForzaNapoliSempre3:14 AM · Jan 11, 202263930AP3️⃣7️⃣ 🚜💙 #ForzaNapoliSempre https://t.co/BS8qyJKiJ2Napoli vs Fiorentina Head-to-HeadNapoli have an excellent record against Fiorentina and have won 17 out of 31 matches played between the two teams. Fiorentina have managed six victories against Napoli and will need to step up on Wednesday.The previous meeting between the two teams took place in October last year and ended in a 2-1 victory for Napoli. Fiorentina gave a good account of themselves on the day but will need to be more robust this week.Napoli form guide: W-D-L-W-LFiorentina form guide: L-D-D-W-WNapoli vs Fiorentina Team NewsNapoli have a depleted squadNapoliNapoli have three players ruled out with COVID-19 this week, including the likes of Hirving Lozano and Victor Osimhen. Kevin Malcuit is also injured and will not be included in the squad.Injured: Kevin MalcuitSuspended: NoneUnavailable: Victor Osimhen, Hirving Lozano, Alex Meret, Adam Ounas, Kalibou Koulibaly, Andre-Frank Zambo AnguissaFiorentina need to win this gameFiorentinaMarco Benassi and Riccardo Sottil are injury concerns for La Viola and will not be able to play a part in this match. Sofyan Amrabat is on international duty at the moment and will be unavailable for selection.Injured: Marco Benassi, Riccardo SottilSuspended: NoneUnavailable: Sofyan AmrabatNapoli vs Fiorentina Predicted XINapoli Predicted XI (4-3-3): David Ospina; Faouzi Ghoulam, Juan Jesus, Amir Rrahmani, Giovanni Di Lorenzo; Diego Demme, Piotr Zielinski, Fabian Ruiz; Andrea Petagna, Matteo Politano, Dries MertensACF Fiorentina English@ACFFiorentinaENJonathan Ikone made his Fiorentina debut ⚜️#ForzaViola #Fiorentina #ACFFiorentina3:30 AM · Jan 11, 2022433Jonathan Ikone made his Fiorentina debut ⚜️#ForzaViola 💜 #Fiorentina #ACFFiorentina https://t.co/kyMeJSW1PMFiorentina Predicted XI (4-3-3): Bartlomiej Dragowski; Aleksa Terzic, Nikola Milenkovic, Lucas Martínez Quarta, Alvaro Odriozola; Erick Pulgar, Joseph Alfred Duncan, Giacomo Bonaventura; Riccardo Saponara, Jonathan Ikone, Dusan VlahovicNapoli vs Fiorentina PredictionNapoli have endured a slight slump over the past month and will need to revert to their exhilarating early-season form this week. The hosts have been impressive against Fiorentina in the past and will need to be wary of an upset in this knock-out fixture.Fiorentina have managed only two points in their last three league games and have a point to prove at the moment. Napoli have been the better team this season, however, and should be able to win this game.Prediction: Napoli 3-1 Fiorentina