Real Madrid host Manchester City at the Santiago Bernabeu in the second leg of the semi-finals of the 2021-22 Champions League on May 4. With the first leg ending 4-3 in favor of City, the onus is all on Los Blancos to make it count at home.The Spanish giants registered their 35th La Liga title triumph last weekend and will be buzzing with a lot of confidence. That being said, City will not be easy to beat given the firepower they have at their disposal.Real Madrid and Manchester City have been superb this seasonThe margin for error in such an intense game will be immensely slim. Both teams had the chance to rest some of their key players over the weekend.This perfectly sets us up for an entertaining second leg of the semi-finals. Here, we take a look at how Real Madrid could line-up to have a good chance of winning the fixture against the defending Premier League champions.Formation: 4-3-3GK: Thibaut CourtoisManchester City v Real Madrid Semi Final Leg One - UEFA Champions LeagueThe Belgian goalkeeper was on the receiving end of four goals in the first leg. Nevertheless, Thibaut Courtois has been a reliable figure between the sticks and will definitely be Madrid's first-choice goalkeeper in the second leg.He has only been able to keep four clean sheets in the Champions League this season. Courtois' task only gets difficult with Manchester City not known to sit back and the hosts will attack full throttle when given the chance.RB: Dani CarvajalReal Madrid v Chelsea FC Quarter Final Leg Two - UEFA Champions LeagueDani Carvajal has a lot of experience under his belt. He has played some big matches for Los Blancos and will need to be at his very best against City.With the likes of Phil Foden, Jack Grealish and Raheem Sterling likely to test him, Carvajal will have to tackle them tactfully. The Spanish full-back will have to be equally active in attack to help Madrid register a successful come-back.CB: Eder MilitaoManchester City v Real Madrid Semi Final Leg One - UEFA Champions LeagueEder Militao did not have the best of times in the first leg at the Etihad. The Brazilian defender was criticized by Madrid fans for being vulnerable to the dangerous City attack.WhoScored.com@WhoScoredEder Militao's last four Champions League appearances #UCL:🟨 vs Chelsea vs PSG🟨 vs PSG🟨 vs Inter Booked in three of his last four464Eder Militao's last four Champions League appearances #UCL:🟨 vs Chelsea😇 vs PSG🟨 vs PSG🟨 vs Inter😡 Booked in three of his last fourThere is not enough time to ponder and Millitao will have to bounce back strongly in the second leg. He has to be at his defensive best if Madrid are to beat City convincingly.CB: NachoReal Madrid v Paris Saint-Germain: Round Of Sixteen Leg Two - UEFA Champions LeagueNacho has been in and out of the side this season. The Spaniard has failed to make a continuous run in the starting XI with Militao and David Alaba being the first-choice centre-backs.Clarisse Uwimana@uwimaclarisseOFFICIAL | David Alaba will miss the second leg of Real Madrid's Champions League semi-final with Manchester City on Wednesday night.The Austrian was forced off at the interval in the first leg last Tuesday. Yoooo disiii 🥲🥲392OFFICIAL | David Alaba will miss the second leg of Real Madrid's Champions League semi-final with Manchester City on Wednesday night.The Austrian was forced off at the interval in the first leg last Tuesday. Yoooo disiii 🥲🥲 https://t.co/8Ry9uWMQaDHowever, with Alaba ruled out of the second leg due to an injury, Nacho will have to fill his shoes. It is a massive responsibility given the stature of the game. His partnership with Militao will be a crucial element in the outcome of this entertaining fixture.LB: Ferland MendyReal Madrid v Chelsea FC Quarter Final Leg Two - UEFA Champions LeagueMarcelo was used as a left-back at the weekend in their 4-0 win over Espanyol, which is why Ferland Mendy is very likely to start against City. The French full-back has struggled with consistency at times but will have little room for error against Manchester City.Mendy's contribution in attack will be equally important as he will be up against the attacking Joao Cancelo, who could be caught out of position. The 26-year-old has three assists in the Champions League this season and could add more to his tally with the right performance against City. Incidentally, two his three assists came against City in the first leg itself.CDM: CasemiroChelsea FC v Real Madrid Quarter Final Leg One - UEFA Champions LeagueThe Brazilian midfielder went unused in the first leg of the semi-finals. It did come as a surprise but maybe manager Carlo Ancelotti had something else on his mind.Madrid Zone@theMadridZone| Real Madrid are open to offers for Casemiro. Juventus and PSG are the most interested clubs at the moment. @UOLEsporte #rmalive4009173🚨🚨| Real Madrid are open to offers for Casemiro. Juventus and PSG are the most interested clubs at the moment. @UOLEsporte #rmaliveWith his defensive abilities, Casemiro can provide the perfect protection to his defenders and can time and again help them out. He will be a key player in breaking City's attack and disrupting their flow time and again.CM: Luka ModricManchester City v Real Madrid Semi Final Leg One - UEFA Champions LeagueThe experienced Croatian has been an instrumental figure for Real Madrid despite his age. The 36-year-old midfielder has been superb in the Champions League this campaign.Bolarinwa Olajide@iambolarReal Madrid’s Luka Modric: “We’re lucky? Don’t make me laugh. It’s an unfair opinion. You don’t get to a Champions League semifinal by being lucky. We’re focusing on our job and not what the media says.”#UCL467Real Madrid’s Luka Modric: “We’re lucky? Don’t make me laugh. It’s an unfair opinion. You don’t get to a Champions League semifinal by being lucky. We’re focusing on our job and not what the media says.”#UCLHis forward-passing, combined with his creative abilities, has been a delight to watch. Luka Modric will have to play a massive role to ensure Madrid a place in the final in Paris.CM: Toni KroosReal Madrid v Chelsea FC Quarter Final Leg Two - UEFA Champions LeagueToni Kroos was rather ineffective against Manchester City in the first leg. With his experience and quality, he was expected to do better but somehow it didn't happen.Nevertheless, he remains a big player and can turn the game around with his world-class passing and creative abilities. Kroos should start against City and use all his vast experience to help the team reach the final.RW: RodrygoReal Madrid v Chelsea FC Quarter Final Leg Two - UEFA Champions LeagueRodrygo did start against Espanyol at the weekend in La Liga. Having scored twice then, the Brazilian must be high on confidence.Given how much Ancelotti has trusted Rodrygo more in comparison to Marco Asensio and Gareth Bale, he is most likely to start against City. The 21-year-old has scored thrice and registered two assists in just four starts in the Champions League this season.LW: Vinicius JuniorManchester City v Real Madrid Semi Final Leg One - UEFA Champions LeagueOne of Real Madrid's most important players this season has been young Vinicius Junior. The Brazilian's blistering pace, amazing dribbling and fine goal-scoring abilities have brought a lot of goals for Los Blancos.WhoScored.com@WhoScored Vinicius Junior has scored or assisted in each of Real Madrid's last four Champions League matches in the knock-out stage #UCL36526🔥 Vinicius Junior has scored or assisted in each of Real Madrid's last four Champions League matches in the knock-out stage #UCL https://t.co/VmdJnEutc6Vinicius Junior has already scored thrice and registered six assists in the Champions League this campaign, including a goal in the first leg. The 21-year-old will have to be influential in helping Madrid put on a strong fight in the second leg.ST: Karim BenzemaManchester City v Real Madrid Semi Final Leg One - UEFA Champions LeagueNo striker right now is feared as much as Karim Benzema. The Frenchman has had a terrific Champions League campaign, having scored 14 goals in the competition.UEFA Champions League@ChampionsLeagueKarim @Benzema is having some season #UCL216621345Karim @Benzema is having some season 🔥#UCL https://t.co/ThCtZdmdd3He was on the scoresheet twice in the first leg and will definitely play a key role in the second leg. Manchester City will have to make sure to contain Benzema well if they are to ensure a place in the finals.