Latin American powerhouses Argentina and Chile kick things off in the 2021 Copa America with a mouth-watering clash at the Estádio Olímpico Nilton Santos in Rio de Janeiro on Monday.The sides, who contested the 2015 and 2016 finals before locking horns in the third-place playoffs of the 2019 edition, also recently played a World Cup qualifying encounter.Barcelona superstar Lionel Messi put La Albiceleste ahead from the spot before Alexis Sanchez equalized for the Reds to secure a 1-1 draw. However, both teams will be aiming for a better result here.Lionel Scaloni's side are the obvious favorites, and their vastly superior head-to-head record also holds them in good stead. But their southern rivals will be a tough proposition, having ruffled their feathers in past Copa encounters.Argentina vs Chile Head-To-HeadIn 93 previous clashes between the sides, Chile have beaten Argentina just eight times, and lost in a staggering 61 games.Their last two meetings, however, have both ended in stalemates, a goalless affair in a 2019 friendly before a share of the spoils in this month's World Cup qualifier.🇨🇱⚽ NÓMINA DE #LAROJA PARA LA COPA AMÉRICA‼ 💪 Listos los 2⃣8⃣ futbolistas que participarán en el torneo continental#VamosLaRoja pic.twitter.com/QxnAYY6bji— Selección Chilena (@LaRoja) June 10, 2021Argentina Form Guide (all competitions): W-D-W-D-DChile Form Guide (all competitions): W-L-W-D-DAlso Read: Fabrizio Romano’s Transfer Roundup: Update on Lionel Messi’s contract, Chelsea’s plan for the summer and moreArgentina vs Chile Team NewsArgentinaGoalkeeper Emiliano Martinez is now fully fit and available for this encounter.Fellow keeper Franco Armani has finally tested negative for COVID-19 and is able to feature against Chile if called upon. Aston Villa attacker Emiliano Buendia and Sevilla forward Lucas Ocampos have not been included in the Copa America squad.Injured: NoneSuspended: NoneUnavailable/COVID-19: None#SelecciónMayor Lista de convocados 📋🇦🇷 por el entrenador @lioscaloni para disputar la #CopaAmérica2021. pic.twitter.com/E5pgpQ0fLz— Selección Argentina 🇦🇷 (@Argentina) June 11, 2021ChileLa Roja have a clean bill of health going into the game and manager Martin Lasarte might opt to revert to a four-man backline after playing 3-4-3 against Bolivia.Alexis Sanchez picked up an injury in training and will not be available against Argentina. Felipe Mora could be brought in to replace him alongside prolific striker Eduardo Vargas in a two-pronged attack.Injured: NoneSuspended: NoneUnavailable: NoneArgentina vs Chile Predicted XIArgentina (4-3-3): Emiliano Martinez; Gonzalo Montiel, Cristian Romero, Nicolas Otamendi, Marcos Acuna; Giovani Lo Celso, Leandro Paredes, Rodrigo De Paul, Angel Di Maria; Lionel Messi, Lautaro Martinez.Chile (4-4-2): Claudio Bravo; Mauricio Isla, Gary Medel, Guillermo Maripan, Eugenio Mena; Arturo Vidal, Eric Pulgar, Charles Aranguiz, Jean Meneses; Felipe Mora, Eduardo Vargas.Argentina vs Chile PredictionChile's back-to-back Copa titles against the Sky Blues now seem like a distant memory. Meanwhile, their record in recent World Cup qualifying games hasn't been particularly stellar either.Argentina, despite all their flaws and chronic Messi-dependency, are better-placed to win the match and should be able to see them off narrowly.Prediction: Argentina 2-1 ChileKindly help Sportskeeda's Football section improve. Take a 30-second survey now.